BVB and Bayer set to qualify

Borussia Dortmund have arrived in London for their third visit to the Emirates in as many years. Injury to Marco Reus - his third major injury of 2014 - and the loss of two points last weekend to Bundesliga surprise-package Paderborn have Dortmund limping their way out of this season's rut. Once again though, the club's spotless European form looks set to be their saving grace.

Having lost 2-1 away to Arsenal in 2011, Dortmund then won by the same scoreline on their last visit to England's capital and, despite the loss of their star player for the rest of the year, can be confident of something similar on Wednesday night.

Arsenal woefully threw away a three-goal lead last time out against Anderlecht and haven't won in the Premier League since the start of November. Despite that, they are second in Group D, five points behind group-leaders Dortmund, but also five points ahead of Anderlecht in second. Coach Arsene Wenger is expected to make changes after the 2-1 defeat to Manchester United last weekend - midfielder Jack Wilshere is out injured.

Apart from Reus, Dortmund will also be without defenders Mats Hummels and Sokratis Papastathopoulos. Despite that, chairman Hans-Joachim Watzke has asked for "blood, sweat and tears" even though a draw will see both sides through.

Pharmaceuticals face bankers

Ever since they met in the opening game of Group C, Monaco and Leverkusen's form has been polar opposites. Roger Schmidt's men lost by a solitary goal in France, but went on to reel off three straight wins and now top the group. At home on Wednesday night, all Leverkusen need is a point to progress to the knockout-rounds for the second consecutive campaign.

Bayer's form in Europe has been matched by an increased consistency in the Bundesliga too. In their 3-1 win against Hannover last weekend, striker Stefan Kiessling scored for the first time since August and Gonzalo Castro and Simon Rolfes returned from long injury absences. All the signs are pointing towards further success for Leverkusen - who have only lost three games under Schmidt.

Monaco, on the other hand, have struggled in Ligue 1. A 2-2 draw against lowly Caen on Saturday leaves them eighth in the league, and coach Leonardo Jardim feels his team lack efficiency and a stronger mentality.

Having not scored in five of their last six European away trips, Monaco will need goals on Wednesday night to stand a chance of progressing.

Elsewhere in Europe

Anderlecht know a win against Galatasaray would keep their slim chances of progression alive, should Arsenal fall at home to Dortmund. The same could be said for both Zenit and Benfica, who are only one point behind Monaco in Group C.

In Group A, Juventus are battling to progress and will need a win in Sweden against Malmo to put pressure on second-placed Olympiakos, who play group-leaders Atletico Madrid. Real Madrid are flying high at the top of Group B and don't look like losing their 100 percent record away in Basel. Liverpool desperately need a win against Ludogorets having collected only three points from four games.